A population-based longitudinal study conducted in Korea has shown that lower levels of high-density lipoprotein cholesterol (HDL-C) and greater HDL-C variability are associated with a higher incidence of Parkinsons disease.

In the study, older adults with the lowest quartile of baseline HDL-C appeared to have higher incidence of Parkinsons disease over a 5-year period, with adjusted HR of 1.20, in comparison with those in the highest quartile group. Individuals with the highest levels of HDL-C variability had increased odds of incident Parkinsons disease (adjusted HR 1.19) in comparison with those who had the least variability. Those with both lowest baseline HDL-C level and highest HDL-C variability were found to have the highest risk of developing Parkinsons disease (adjusted HR 1.6). The findings are published in the journal Neurology… (Medpage Today)